Human liver?derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR?independent activation

Mucosal associated invariant T (MAIT) cells are anti-microbial innate-like that abundant in blood and liver. MAIT express a semi-invariant T-cell receptor (TCR) recognizes pyrimidine ligand, derived from microbial riboflavin synthesis, bound to MR1. Both liver (ld)-MAIT can be robustly stimulated via TCR or by cytokines produced during bacterial viral infection. In this study, we compared the functional transcriptomic response of human ld-MAIT signals (Escherichia coli ligand) (IL-12 + IL-18). While were comparable, following cytokine stimulation more polyfunctional than cells. Transcriptomic analysis demonstrated different effector programmes with two modes activation, including enrichment tissue repair signature TCR-stimulated Interestingly, observed enhancement IL-12 signaling fatty acid metabolism untreated Additionally, modulated similarly signals. Therefore, report fundamentally but undergo conserved changes activation cytokines.